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中文标题
遗传背景决定实验性癌症演化的轨迹
English Title
Genetic background sets the trajectory of experimental cancer evolution
Sarah J. Aitken
发布时间
2026/7/22 08:00:00
来源类型
blog
语言
en
摘要
中文对照
人类癌症具有异质性¹。利用人类数据集解析种系遗传变异和环境因素如何塑造肿瘤演化，受限于遗传背景固有的多样性²以及环境暴露的差异³⁻⁵。为克服这些限制，我们在多个遗传分化的近交小鼠品系中重复开展了数百次早期肿瘤演化实验，并获取了匹配的组织病理学、全基因组及转录组测序数据。
English Original
Human cancers are heterogeneous1. Dissecting how germline genetic variation and environmental factors shape tumour evolution using human datasets is limited by inherent diversity in genetic backgrounds2 and environmental exposures3–5. Here, to overcome these limitations, we re-ran early tumour evolution hundreds of times in diverged inbred mouse strains, generating matched histology and whole-genome and transcriptome sequences.
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