重大指导文件清单，包括向受监管实体或公众分发的指导文件，这些文件预计可能对经济产生每年1亿美元以上的年度影响，或对经济、经济部门、生产力、竞争、就业、环境、公共卫生或安全、州、地方或部落政府或社区造成实质性不利影响；造成严重不一致或干扰其他机构已采取或计划采取的行动；实质性改变福利、拨款、使用费或贷款计划的预算影响或其接受者的权利和义务；或引发源于法律授权、总统优先事项或经进一步修订的第12866号行政命令所确立原则的新颖法律或政策问题。

A list of Significant Guidance documents, which include guidance document disseminated to regulated entities or the general public that may reasonably be anticipated to lead to an annual effect on the economy of $100 million or more or adversely affect in a material way the economy, a sector of the economy, productivity, competition, jobs, the environment, public health or safety, or State, local, or tribal governments or communities; create a serious inconsistency or otherwise interfere with an action taken or planned by another agency; materially alter the budgetary impact of entitlements, grants, user fees, or loan programs or the rights and obligations of recipients thereof; or raise novel legal or policy issues arising out of legal mandates, the President's priorities, or the principles set forth in Executive Order 12866, as further amended.